A DNA-damaging oxoaporphine alkaloid from Piper caninum.

  title={A DNA-damaging oxoaporphine alkaloid from Piper caninum.},
  author={Ji Ma and Shannon H Jones and Rebekah E Marshall and Randall K. Johnson and Sidney M Hecht},
  journal={Journal of natural products},
  volume={67 7},
Bioassay-guided fractionation of an active organic extract of Piper caninum, using a sensitive yeast assay to monitor putative double-strand DNA-damaging activity, resulted in the isolation of the 4,5-dioxoaporphine alkaloid cepharadione A (1). Compound 1 exhibited potent inhibitory activity in a yeast cytotoxicity assay with IC(50) values of 50.2 nM toward RS321NpRAD52 grown on glucose versus 293 nM toward the same yeast strain grown on galactose. 

From This Paper

Topics from this paper.