A DNA-damaging oxoaporphine alkaloid from Piper caninum.

@article{Ma2004ADO,
  title={A DNA-damaging oxoaporphine alkaloid from Piper caninum.},
  author={Ji Ma and Shannon H Jones and Rebekah E Marshall and Randall K. Johnson and Sidney M Hecht},
  journal={Journal of natural products},
  year={2004},
  volume={67 7},
  pages={
          1162-4
        }
}
Bioassay-guided fractionation of an active organic extract of Piper caninum, using a sensitive yeast assay to monitor putative double-strand DNA-damaging activity, resulted in the isolation of the 4,5-dioxoaporphine alkaloid cepharadione A (1). Compound 1 exhibited potent inhibitory activity in a yeast cytotoxicity assay with IC(50) values of 50.2 nM toward RS321NpRAD52 grown on glucose versus 293 nM toward the same yeast strain grown on galactose. 

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