A DNA damage response pathway controlled by Tel1 and the Mre11 complex.

@article{Usui2001ADD,
  title={A DNA damage response pathway controlled by Tel1 and the Mre11 complex.},
  author={Takehiko Usui and Hidehiko Ogawa and John H.J Petrini},
  journal={Molecular cell},
  year={2001},
  volume={7 6},
  pages={1255-66}
}
We define a DNA damage checkpoint pathway in S. cerevisiae governed by the ATM homolog Tel1 and the Mre11 complex. In mitotic cells, the Tel1-Mre11 complex pathway triggers Rad53 activation and its interaction with Rad9, whereas in meiosis it acts via Rad9 and the Rad53 paralog Mre4/Mek1. Activation of the Tel1-Mre11 complex pathway checkpoint functions appears to depend upon the Mre11 complex as a damage sensor and, at least in meiotic cells, to depend on unprocessed DNA double-strand breaks… CONTINUE READING
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