A DNA-centric protein interaction map of ultraconserved elements reveals contribution of transcription factor binding hubs to conservation.

@article{Viturawong2013ADP,
  title={A DNA-centric protein interaction map of ultraconserved elements reveals contribution of transcription factor binding hubs to conservation.},
  author={Tar Viturawong and Felix Mei\ssner and Falk Butter and Matthias Mann},
  journal={Cell reports},
  year={2013},
  volume={5 2},
  pages={531-45}
}
Ultraconserved elements (UCEs) have been the subject of great interest because of their extreme sequence identity and their seemingly cryptic and largely uncharacterized functions. Although in vivo studies of UCE sequences have demonstrated regulatory activity, protein interactors at UCEs have not been systematically identified. Here, we combined high-throughput affinity purification, high-resolution mass spectrometry, and SILAC quantification to map intrinsic protein interactions for 193 UCE… CONTINUE READING
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