A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence.

@article{Fan1990ADP,
  title={A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence.},
  author={C M Fan and Tom Maniatis},
  journal={Genes & development},
  year={1990},
  volume={4 1},
  pages={29-42}
}
We have isolated a full-length cDNA clone encoding a protein (PRDII-BF1) that binds specifically to a positive regulatory domain (PRDII) of the human IFN-beta gene promoter, and to a similar sequence present in a number of other promoters and enhancers. The sequence of this protein reveals two novel structural features. First, it is the largest sequence-specific DNA-binding protein reported to date (298 kD). Second, it contains two widely separated sets of C2-H2-type zinc fingers. Remarkably… CONTINUE READING

From This Paper

Topics from this paper.
54 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 54 extracted citations

Similar Papers

Loading similar papers…