A DNA-Dependent Protease Involved in DNA-Protein Crosslink Repair

  title={A DNA-Dependent Protease Involved in DNA-Protein Crosslink Repair},
  author={Julian Stingele and Michael Schwarz and Nicolas Bloemeke and Peter G Wolf and Stefan Jentsch},
Toxic DNA-protein crosslinks (DPCs) arise by ionizing irradiation and UV light, are particularly caused by endogenously produced reactive compounds such as formaldehyde, and also occur during compromised topoisomerase action. Although nucleotide excision repair and homologous recombination contribute to cell survival upon DPCs, hardly anything is known about mechanisms that target the protein component of DPCs directly. Here, we identify the metalloprotease Wss1 as being crucial for cell… CONTINUE READING
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