A DNA Damage Signal Is Required for p 53 to Activate gadd 45 1

@inproceedings{Xiao2000ADD,
  title={A DNA Damage Signal Is Required for p 53 to Activate gadd 45 1},
  author={Gu Xiao and Agustin Chicas and Magali Olivier and Yoichi Taya and Sanjay Tyagi and Fred Rusell Kramer and Jill Bargonetti},
  year={2000}
}
We provide direct evidence that overexpression of p53 is not sufficient for robust p53-dependent activation of the endogenous gadd45gene. When p53 was induced in TR9-7 cells in the absence of DNA damage, waf1/p21 and mdm2 mRNA levels were increased, but a change in gadd45 mRNA was barely detectable. Activation of thegadd45gene was observed when camptothecin was added to cells containing p53 in the absence of a further increase in the p53 level. Phosphorylation of p53 at serine 15 and… CONTINUE READING

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