A DNA Damage-Induced, SOS-Independent Checkpoint Regulates Cell Division in Caulobacter crescentus

@inproceedings{Modell2014ADD,
  title={A DNA Damage-Induced, SOS-Independent Checkpoint Regulates Cell Division in Caulobacter crescentus
},
  author={Joshua Wexler Modell and Tracy K. Kambara and Barrett S. Perchuk and Michael T Laub},
  booktitle={PLoS biology},
  year={2014}
}
Cells must coordinate DNA replication with cell division, especially during episodes of DNA damage. The paradigm for cell division control following DNA damage in bacteria involves the SOS response where cleavage of the transcriptional repressor LexA induces a division inhibitor. However, in Caulobacter crescentus, cells lacking the primary SOS-regulated inhibitor, sidA, can often still delay division post-damage. Here we identify didA, a second cell division inhibitor that is induced by DNA… CONTINUE READING

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  • Proceedings of the National Academy of Sciences of the United States of America
  • 2016
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 53 REFERENCES

Assembly of the Caulobacter cell division machine.

  • Molecular microbiology
  • 2011
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

BapE DNA endonuclease induces an apoptotic-like response to DNA damage in Caulobacter.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2012
VIEW 1 EXCERPT

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