A DHA14 drug efflux gene from Xanthomonas albilineans confers high-level albicidin antibiotic resistance in Escherichia coli.

@article{Bostock2006ADD,
  title={A DHA14 drug efflux gene from Xanthomonas albilineans confers high-level albicidin antibiotic resistance in Escherichia coli.},
  author={Julieanne M Bostock and Guangming Huang and Saeed M. Hashimi and Li-qun Zhang and Robert G. Birch},
  journal={Journal of applied microbiology},
  year={2006},
  volume={101 1},
  pages={151-60}
}
AIMS Identification of a gene for self-protection from the antibiotic-producing plant pathogen Xanthomonas albilineans, and functional testing by heterologous expression. METHODS AND RESULTS Albicidin antibiotics and phytotoxins are potent inhibitors of prokaryote DNA replication. A resistance gene (albF) isolated by shotgun cloning from the X. albilineans albicidin-biosynthesis region encodes a protein with typical features of DHA14 drug efflux pumps. Low-level expression of albF in… CONTINUE READING
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