A DFT study on the formation of a phosphohistidine intermediate in prostatic acid phosphatase.


Histidine phosphatases are a class of enzymes that are characterized by the presence of a conserved RHGXRXP motif. This motif contains a catalytic histidine that is being phosphorylated in the course of a dephosphorylation reaction catalyzed by these enzymes. Prostatic acid phosphatase (PAP) is one such enzyme. The dephosphorylation of phosphotyrosine by… (More)
DOI: 10.1021/ja710047a


14 Figures and Tables