A DFT study of the mechanisms and regio- and stereochemistry of the lewis acid-catalyzed reactions of 5-alkoxyoxazoles with aldehydes: aryl substitution at the 2-position of 5-alkoxyoxazole is critical to the formation of 4-alkoxycarbonyl-2-oxazoline.

Abstract

Density functional theory at the B3LYP/6-31G level has been used to study the mechanisms and regio- and stereochemistry of the Lewis acid-catalyzed reactions of aldehydes with 5-alkoxyoxazoles. Similar to the uncatalyzed reaction between aldehyde and 5-methoxyoxazole, which has an activation energy of 30.5 kcal/mol and intrinsically favors production of 2… (More)

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@article{Yu2003ADS, title={A DFT study of the mechanisms and regio- and stereochemistry of the lewis acid-catalyzed reactions of 5-alkoxyoxazoles with aldehydes: aryl substitution at the 2-position of 5-alkoxyoxazole is critical to the formation of 4-alkoxycarbonyl-2-oxazoline.}, author={Zhi-Xiang Yu and Yun-Dong Wu}, journal={The Journal of organic chemistry}, year={2003}, volume={68 2}, pages={421-32} }