A DAF-16/FoxO3a-dependent longevity signal is initiated by antioxidants.

  title={A DAF-16/FoxO3a-dependent longevity signal is initiated by antioxidants.},
  author={Juewon Kim and Naoko Ishihara and Tae Ryong Lee},
  volume={40 2},
The precise mechanisms of antioxidant-mediated longevity are poorly understood. We show that an antioxidant treatment can extend the lifespan of Caenorhabditis elegans (C. elegans) through the nuclear translocation of the forkhead box O transcription factor (FoxO) homolog DAF-16. This pathway was found to involve 3-phosphoinositide-dependent kinase-1 (PDK-1) and serum- and glucocorticoid-regulated kinase-1 (SGK-1), distinct from the known oxidative stress-mediated mechanism in which FoxO3a… CONTINUE READING
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