A D2 Class Dopamine Receptor Transactivates a Receptor Tyrosine Kinase to Inhibit NMDA Receptor Transmission

@article{Kotecha2002ADC,
  title={A D2 Class Dopamine Receptor Transactivates a Receptor Tyrosine Kinase to Inhibit NMDA Receptor Transmission},
  author={Suhas Ashok Kotecha and James N Oak and Michael F Jackson and Yael Perez and Beverley A. Orser and Hubert H.M Van Tol and John F. Macdonald},
  journal={Neuron},
  year={2002},
  volume={35},
  pages={1111-1122}
}
Receptor tyrosine kinases (RTKs) are membrane spanning proteins with intrinsic kinase activity. Although these receptors are known to be involved in proliferation and differentiation of cells, their roles in regulating central synaptic transmission are largely unknown. In CA1 pyramidal neurons, activation of D2 class dopamine receptors depressed excitatory transmission mediated by the NMDA subtype of glutamate receptor. This depression resulted from the quinpirole-induced release of… CONTINUE READING

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