A Cytoplasmic RNA Vector Derived from Nontransmissible Sendai Virus with Efficient Gene Transfer and Expression

@article{Li2000ACR,
  title={A Cytoplasmic RNA Vector Derived from Nontransmissible Sendai Virus with Efficient Gene Transfer and Expression},
  author={Hai-ou Li and Yafeng Zhu and Makoto Asakawa and Hidekazu Kuma and Takahiro Hirata and Yasuji Ueda and Yun-Sik Lee and Masayuki Fukumura and Akihiro Iida and Atsushi Kato and Yoshiyuki Nagai and Mamoru Hasegawa},
  journal={Journal of Virology},
  year={2000},
  volume={74},
  pages={6564 - 6569}
}
ABSTRACT We have recovered a virion from defective cDNA of Sendai virus (SeV) that is capable of self-replication but incapable of transmissible-virion production. This virion delivers and expresses foreign genes in infected cells, and this is the first report of a gene expression vector derived from a defective viral genome of theParamyxoviridae. First, functional ribonucleoprotein complexes (RNPs) were recovered from SeV cloned cDNA defective in the F (envelope fusion protein) gene, in the… 
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