A Cypher/ZASP mutation associated with dilated cardiomyopathy alters the binding affinity to protein kinase C.

@article{Arimura2004ACM,
  title={A Cypher/ZASP mutation associated with dilated cardiomyopathy alters the binding affinity to protein kinase C.},
  author={Takuro Arimura and Takeharu Hayashi and Hajime Terada and S Lee and Qiang Zhou and Megumi Takahashi and Kazuo Ueda and Tatsuhito Nouchi and Shigeru Hohda and Makoto Shibutani and Masao Hirose and Ju Chen and J S Park and Michio Yasunami and Hideharu Hayashi and Akinori Kimura},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 8},
  pages={6746-52}
}
Dilated cardiomyopathy is characterized by ventricular dilation with systolic dysfunction of cardiac muscle. Recent genetic studies have revealed that mutations in genes for cytoskeleton proteins distributed in the Z-disc and/or intercalated discs of the cardiac muscle are major predictors of cardiomyopathy. However, as mutations in these genes can account for only a part of the patient population, there should be another disease-causing gene(s) for cardiomyopathy. Cypher/ZASP appears to be an… CONTINUE READING

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