A Cyclized Helix-Loop-Helix Peptide as a Molecular Scaffold for the Design of Inhibitors of Intracellular Protein-Protein Interactions by Epitope and Arginine Grafting.

Abstract

The design of inhibitors of intracellular protein-protein interactions (PPIs) remains a challenge in chemical biology and drug discovery. We propose a cyclized helix-loop-helix (cHLH) peptide as a scaffold for generating cell-permeable PPI inhibitors through bifunctional grafting: epitope grafting to provide binding activity, and arginine grafting to endow… (More)
DOI: 10.1002/anie.201603230

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Cite this paper

@article{Fujiwara2016ACH, title={A Cyclized Helix-Loop-Helix Peptide as a Molecular Scaffold for the Design of Inhibitors of Intracellular Protein-Protein Interactions by Epitope and Arginine Grafting.}, author={Daisuke Fujiwara and Hidekazu Kitada and Masahiro Oguri and Toshio Nishihara and Masataka Michigami and Kazunori Shiraishi and Eiji Yuba and Ikuhiko Nakase and Haeri Im and Sunhee Cho and Jong Young Joung and Seiji Kodama and Kenji Kono and Sihyun Ham and Ikuo Fujii}, journal={Angewandte Chemie}, year={2016}, volume={55 36}, pages={10612-5} }