A Cu(I)-sensing ArsR family metal sensor protein with a relaxed metal selectivity profile.

@article{Liu2008ACA,
  title={A Cu(I)-sensing ArsR family metal sensor protein with a relaxed metal selectivity profile.},
  author={Tong Liu and Xiaohua Chen and Zhen Ma and Jacob E. Shokes and Lars Hemmingsen and Robert Scott and David P Giedroc},
  journal={Biochemistry},
  year={2008},
  volume={47 40},
  pages={10564-75}
}
ArsR (or ArsR/SmtB) family metalloregulatory homodimeric repressors collectively respond to a wide range of metal ion inducers in regulating homeostasis and resistance of essential and nonessential metal ions in bacteria. BxmR from the cyanobacterium Osciliatoria brevis is the first characterized ArsR protein that senses both Cu (I)/Ag (I) and divalent metals Zn (II)/Cd (II) in cells by regulating the expression of a P-type ATPase efflux pump (Bxa1) and an intracellular metallothionein (BmtA… CONTINUE READING

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Mentioned Connections BETA
Unlike the other metals ions , the BxmR dimer binds 4 mol equiv of Cu ( I ) to form an alpha3N binuclear Cu ( I ) 2S 4 cluster by X - ray absorption spectroscopy .
MetalsNo subtypeCopper
Unlike the other metals ions , the BxmR dimer binds 4 mol equiv of Cu ( I ) to form an alpha3N binuclear Cu ( I ) 2S 4 cluster by X - ray absorption spectroscopy .
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