A Crystallographic Examination of Predisposition versus Preorganization in de Novo Designed Metalloproteins.


Preorganization and predisposition are important molecular recognition concepts exploited by nature to obtain site-specific and selective metal binding to proteins. While native structures containing an MS3 core are often unavailable in both apo- and holo-forms, one can use designed three-stranded coiled coils (3SCCs) containing tris-thiolate sites to… (More)
DOI: 10.1021/jacs.6b07165

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