A Crucial Role of Flagellin in the Induction of Airway Mucus Production by Pseudomonas aeruginosa

@inproceedings{Mohamed2012ACR,
  title={A Crucial Role of Flagellin in the Induction of Airway Mucus Production by Pseudomonas aeruginosa},
  author={Fatima Ben Mohamed and Ignacio Garcia-Verdugo and Mathieu Medina and Viviane Balloy and Michel Chignard and Reuben Ramphal and Lhousseine Touqui},
  booktitle={PloS one},
  year={2012}
}
Pseudomonas aeruginosa is an opportunistic pathogen involved in nosocomial infections. Flagellin is a P. aeruginosa virulence factor involved in host response to this pathogen. We examined the role of flagellin in P. aeruginosa-induced mucus secretion. Using a mouse model of pulmonary infection we showed that PAK, a wild type strain of P. aeruginosa, induced airway mucus secretion and mucin muc5ac expression at higher levels than its flagellin-deficient mutant (ΔFliC). PAK induced expression of… CONTINUE READING