A Crucial Role in Fertility for the Oyster Angiotensin-Converting Enzyme Orthologue CgACE

@inproceedings{Rivire2011ACR,
  title={A Crucial Role in Fertility for the Oyster Angiotensin-Converting Enzyme Orthologue CgACE},
  author={Guillaume Rivi{\`e}re and Alexandre Fellous and A G Freddy Franco and Benoit Bernay and Pascal Favrel},
  booktitle={PloS one},
  year={2011}
}
Angiotensin-converting enzyme (ACE) is a highly conserved metallopeptidase. In mammals, the somatic isoform governs blood pressure whereas the germinal isoform (tACE) is required for fertility. In Ecdysozoans, ACE-like enzymes are implicated in reproduction. Despite ACE orthologues being present from bacteria to humans, their function(s) remain(s) unknown in distant organisms such as Lophotrochozoans. In silico analysis of an oyster (Crassostrea gigas) EST library suggested the presence of an… CONTINUE READING

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