A Cross-Talk Between Microbiota-Derived Short-Chain Fatty Acids and the Host Mucosal Immune System Regulates Intestinal Homeostasis and Inflammatory Bowel Disease.

@article{Gonalves2018ACB,
  title={A Cross-Talk Between Microbiota-Derived Short-Chain Fatty Acids and the Host Mucosal Immune System Regulates Intestinal Homeostasis and Inflammatory Bowel Disease.},
  author={P. Gonçalves and Jo{\~a}o Ricardo Barbosa Ara{\'u}jo and James P Di Santo},
  journal={Inflammatory bowel diseases},
  year={2018},
  volume={24 3},
  pages={
          558-572
        }
}
Gut microbiota has a fundamental role in the energy homeostasis of the host and is essential for proper "education" of the immune system. Intestinal microbial communities are able to ferment dietary fiber releasing short-chain fatty acids (SCFAs). The SCFAs, particularly butyrate (BT), regulate innate and adaptive immune cell generation, trafficing, and function. For example, BT has an anti-inflammatory effect by inhibiting the recruitment and proinflammatory activity of neutrophils… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 13 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-2 of 2 extracted citations

How human microbiome talks to health and disease

European Journal of Clinical Microbiology & Infectious Diseases • 2018
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…