A Critical Role for Interleukin 18 in Primary and Memory Effector Responses to Listeria monocytogenes That Extends Beyond Its Effects on Interferon γ Production

@article{Neighbors2001ACR,
  title={A Critical Role for Interleukin 18 in Primary and Memory Effector Responses to Listeria monocytogenes That Extends Beyond Its Effects on Interferon γ Production},
  author={Margaret Neighbors and Xiuling Xu and Franck J Barrat and Sigrid R. Ruuls and Tatyana Churakova and Reno Debets and J. Fernando Bazan and Robert A. Kastelein and John S. Abrams and Anne O'Garra},
  journal={The Journal of Experimental Medicine},
  year={2001},
  volume={194},
  pages={343 - 354}
}
The stimulation of interferon (IFN)-gamma by interleukin (IL)-12 has been shown to provide protection from intracellular pathogens such as Listeria monocytogenes. Tumor necrosis factor (TNF) is also a major player in the resolution of Listeria infections and is suggested to have more global effects than can be explained by the induction of IFN-gamma alone. Since IL-18 synergizes with IL-12 to induce IFN-gamma production by natural killer and T helper (Th)1 cells, we determined its role in… CONTINUE READING