A Critical Review of the Fluoroquinolones

  title={A Critical Review of the Fluoroquinolones},
  author={George G Zhanel and Kelly Ennis and Lavern M. Vercaigne and Andrew J. Walkty and Alfred S. Gin and John M. Embil and Heather N Smith and Daryl J. Hoban},
The new fluoroquinolones (clinafloxacin, gatifloxacin, gemifloxacin, grepafloxacin, levofloxacin, moxifloxacin, sitafloxacin, sparfloxacin and trovafloxacin) offer excellent activity against Gram-negative bacilli and improved Gram-positive activity (e.g. against Streptococcus pneumoniae and Staphylococcus aureus) over ciprofloxacin. Ciprofloxacin still maintains the best in vitro activity against Pseudomonas aeruginosa. Clinafloxacin, gatifloxacin, moxifloxacin, sitafloxacin, sparfloxacin and… CONTINUE READING


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