A Critical Review of Electroporation as A Plasmid Delivery System in Mouse Skeletal Muscle

@inproceedings{Sokoowska2019ACR,
  title={A Critical Review of Electroporation as A Plasmid Delivery System in Mouse Skeletal Muscle},
  author={Emilia Sokołowska and Agnieszka Urszula Błachnio-Zabielska},
  booktitle={International journal of molecular sciences},
  year={2019}
}
The gene delivery to skeletal muscles is a promising strategy for the treatment of both muscular disorders (by silencing or overexpression of specific gene) and systemic secretion of therapeutic proteins. The use of a physical method like electroporation with plate or needle electrodes facilitates long-lasting gene silencing in situ. It has been reported that electroporation enhances the expression of the naked DNA gene in the skeletal muscle up to 100 times and decreases the changeability of… CONTINUE READING

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