A Critical Period of Sleep for Development of Courtship Circuitry and Behavior in Drosophila

  title={A Critical Period of Sleep for Development of Courtship Circuitry and Behavior in Drosophila},
  author={Matthew S Kayser and Zhifeng Yue and Amita Sehgal},
Most animals sleep more early in life than in adulthood, but the function of early sleep is not known. Using Drosophila, we found that increased sleep in young flies was associated with an elevated arousal threshold and resistance to sleep deprivation. Excess sleep results from decreased inhibition of a sleep-promoting region by a specific dopaminergic circuit. Experimental hyperactivation of this circuit in young flies results in sleep loss and lasting deficits in adult courtship behaviors… CONTINUE READING
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