A CpG oligonucleotide can protect mice from a low aerosol challenge dose of Burkholderia mallei.

@article{Waag2006ACO,
  title={A CpG oligonucleotide can protect mice from a low aerosol challenge dose of Burkholderia mallei.},
  author={David M. Waag and Michael J McCluskie and Ningli Zhang and Arthur M. Krieg},
  journal={Infection and immunity},
  year={2006},
  volume={74 3},
  pages={1944-8}
}
Treatment with an oligodeoxynucleotide (ODN) containing CPG motifs (CpG ODN 7909) was found to protect BALB/c mice from lung infection or death after aerosol challenge with Burkholderia mallei. Protection was associated with enhanced levels of gamma interferon (IFN-gamma)-inducible protein 10, interleukin-12 (IL-12), IFN-gamma, and IL-6. Preexposure therapy with CpG ODNs may protect victims of a biological attack from glanders. 
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