A Correspondence Between Solution-State Dynamics of an Individual Protein and the Sequence and Conformational Diversity of its Family

@article{Friedland2009ACB,
  title={A Correspondence Between Solution-State Dynamics of an Individual Protein and the Sequence and Conformational Diversity of its Family},
  author={Gregory D. Friedland and Nils-Alexander Lakomek and Christian Griesinger and Jens Meiler and Tanja Kortemme},
  journal={PLoS Computational Biology},
  year={2009},
  volume={5},
  pages={4967 - 4971}
}
Conformational ensembles are increasingly recognized as a useful representation to describe fundamental relationships between protein structure, dynamics and function. Here we present an ensemble of ubiquitin in solution that is created by sampling conformational space without experimental information using "Backrub" motions inspired by alternative… CONTINUE READING