A Correlation Between the Permeability Characteristics of a Series of Peptides Using an in Vitro Cell Culture Model (Caco-2) and Those Using an in Situ Perfused Rat Ileum Model of the Intestinal Mucosa

@article{Kirn1993ACB,
  title={A Correlation Between the Permeability Characteristics of a Series of Peptides Using an in Vitro Cell Culture Model (Caco-2) and Those Using an in Situ Perfused Rat Ileum Model of the Intestinal Mucosa},
  author={D S Kirn and Philip S. Burton and Ronald T. Borchardt},
  journal={Pharmaceutical Research},
  year={1993},
  volume={10},
  pages={1710-1714}
}
In an attempt to establish an in vitro/in situ correlation of intestinal permeability data, the permeability coefficients (P app) for a series of model peptides, which were determined using an in situ perfused rat ileum model, were compared to the permeability coefficients (P mono) determined using an in vitro cell culture model (Caco-2). The model peptides, which were all blocked on the N-terminal (acetyl, Ac) and the C-terminal (amide, NH2) ends, consisted of D-phenylalanine (F) residues (e.g… CONTINUE READING

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