A Core Metabolic Enzyme Mediates Resistance to Phosphine Gas
@article{Schlipalius2012ACM, title={A Core Metabolic Enzyme Mediates Resistance to Phosphine Gas}, author={David I Schlipalius and Nicholas Valmas and Andrew G. Tuck and Rajeswaran Jagadeesan and Li Ma and Ramandeep Kaur and Anita Goldinger and Cameron Anderson and Jujiao Kuang and Steven Zuryn and Yosep Seran Mau and Qiang Cheng and Patrick J. Collins and Manoj Kumar Nayak and Horst Joachim Schirra and Massimo A. Hilliard and Paul R Ebert}, journal={Science}, year={2012}, volume={338}, pages={807 - 810} }
Dissecting Phosphine Resistance Worldwide populations of pest insects—such as the lesser grain borer, Rhyzopertha dominica, and the rust-red flour beetle, Tribolium castaneum—have become highly resistant to the fumigant phosphine, providing a potential threat to global food security. The nematode, Caenorhabditis elegans is vulnerable to phosphine, but phosphine-resistant strains are known. Schlipalius et al. (p. 807) show that mutations in the delta-1-pyrroline-5-carboxylate dehydrogenase and…
134 Citations
Phosphine resistance in India is characterised by a dihydrolipoamide dehydrogenase variant that is otherwise unobserved in eukaryotes
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- 2019
Results reveal two synergists with distinct modes of action of phosphine toxicity, one of which targets individuals that carry a phosphine resistance allele in the dihydrolipoamide dehydrogenase gene.
Identification of a phosphine resistance mechanism in Rhyzopertha dominica based on transcriptome analysis
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- 2018
Unique genetic variants in dihydrolipoamide dehydrogenase (dld) gene confer strong resistance to phosphine in the rusty grain beetle, Cryptolestes ferrugineus (Stephens).
- BiologyPesticide biochemistry and physiology
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Attenuation of radiation toxicity by the phosphine resistance factor dihydrolipoamide dehydrogenase (DLD)
- BiologyScientific Reports
- 2019
The relationship between phosphine toxicity and genotoxic treatments is explored with the goal of understanding how phosphine works and mutant lines either sensitive or resistant to phosphine, gamma irradiation or UV exposure are utilized.
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- Biology
- 2016
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- MedicineInsects
- 2022
It is proposed that lipids offer a consistent energy source for the resistant insect to survive under the stress of phosphine fumigation and provide a suitable environment to protect the mitochondria from phosphine.
RNA-seq Analysis Reveals Mitochondrial and Cuticular Protein Genes Are Associated with Phosphine Resistance in the Rusty Grain Beetle (Coleoptera:Laemophloeidae)
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- 2020
A transcriptome-wide overview of gene expression changes between resistant and susceptible populations of C. ferrugineus is presented, which documents that mitochondria and cuticular protein genes may play together a crucial role in phosphine resistance.
Phosphine resistance does not confer cross-resistance to sulfuryl fluoride in four major stored grain insect pests.
- BiologyPest management science
- 2017
It is concluded that phosphine resistance does not confer cross-resistance to SF in grain insect pests irrespective of the variation in levels of tolerance to SF itself or resistance to phosphine in their egg and adult stages.
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