A Convenient Synthesis of N,N′-dibenzyl-2,4-diaminopyrimidine-2′-deoxyribonucleoside and 1-Methyl-2′-Deoxypseudoisocytidine

@article{Wellington2009ACS,
  title={A Convenient Synthesis of N,N′-dibenzyl-2,4-diaminopyrimidine-2′-deoxyribonucleoside and 1-Methyl-2′-Deoxypseudoisocytidine},
  author={Kevin W Wellington and H. Ooi and S. Benner},
  journal={Nucleosides, Nucleotides & Nucleic Acids},
  year={2009},
  volume={28},
  pages={275 - 291}
}
The syntheses of N,N′-dibenzyl-2,4-diaminopyrimidine-2′-deoxyribonucleoside and 1-methyl-2′-deoxypseudoisocytidine via Heck coupling are described. A survey of the attempts to use the Heck coupling to synthesize N,N′-dibenzyl-2,4-diaminopyrimidine-2′-deoxyribonucleoside is provided, indicating a remarkable diversity in outcome depending on the specific heterocyclic partner used. 
7 Citations
Synthesis of Nonnatural Oligonucleotides Made Exclusively of Alkynyl C‐Nucleosides with Nonnatural Bases
  • J. Chiba, M. Inouye
  • Chemistry, Medicine
  • Current protocols in nucleic acid chemistry
  • 2015

References

SHOWING 1-10 OF 34 REFERENCES
Fluorescent charge-neutral analogue of xanthosine: synthesis of a 2'-deoxyribonucleoside bearing a 5-aza-7-deazaxanthine base.
  • 26
  • PDF
Expanding the genetic alphabet: non-epimerizing nucleoside with the pyDDA hydrogen-bonding pattern.
  • 45
  • PDF
An HIV reverse transcriptase-selective nucleoside chain terminator.
  • 24
Unnatural base pairs for specific transcription
  • 74
  • PDF
Use of pK(a) differences to enhance the formation of base triplets involving C-G and G-C base pairs.
  • 23
Novel benzopyrimidines as widened analogues of DNA bases.
  • 60
...
1
2
3
4
...