A Conserved mRNA Export Machinery Coupled to pre-mRNA Splicing

  title={A Conserved mRNA Export Machinery Coupled to pre-mRNA Splicing},
  author={Robin Reed and Ed Hurt},

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Coupling transcription, splicing and mRNA export.

  • R. Reed
  • Biology
    Current opinion in cell biology
  • 2003

Regulation of pre-mRNA splicing and mRNA degradation in Saccharomyces cerevisiae

In the cytoplasm, mRNAs serve as the template for protein synthesis and are event encoded by messenger RNAs in the nucleus and transported to the cy toplasm.

Directing mRNA export

  • E. Izaurralde
  • Chemistry, Biology
    Nature Structural &Molecular Biology
  • 2004
A recent study on the RNA-binding protein Npl3p reveals how its direct interaction with the mRNA export receptor Mex67p is regulated by phosphorylation and how this post-translational modification

Regulation of mRNP dynamics along the export pathway

RNA‐binding Proteins: Regulation of mRNA Splicing, Export and Decay

Mammalian messenger ribonucleic acid (mRNA)-binding proteins regulate gene expression at several steps including pre-mRNA processing, nucleocytoplasmic export and degradation. Keywords:

mRNA export: an assembly line from genes to nuclear pores.

Alternative pre-mRNA splicing and proteome expansion in metazoans

Alternative pre-mRNA splicing selectively joins different protein coding elements to form mRNAs that encode proteins with distinct functions, and is therefore an important source of protein diversity.

A novel family of nuclear transport receptors mediates the export of messenger RNA to the cytoplasm.

Recent studies in yeast and in higher eukaryotes have led to the elucidation of an evolutionarily conserved pathway for the export of bulk mRNA to the cytoplasm.



Nuclear mRNA export.

  • L. Maquat
  • Biology
    Current opinion in cell biology
  • 1991

Coupling RNA polymerase II transcription with pre-mRNA processing.

  • D. Bentley
  • Biology
    Current opinion in cell biology
  • 1999

A new view of mRNA export: Separating the wheat from the chaff

In this model, the non-hnRNP factors form a splicing-dependent mRNP complex that specifically targets mature mRNA for export, while hnRNP proteins retain introns in the nucleus.

Communication of the Position of Exon-Exon Junctions to the mRNA Surveillance Machinery by the Protein RNPS1

It is demonstrated that the protein RNPS1, a component of the postsplicing complex that is deposited 5′ to exon-exon junctions, interacts with the evolutionarily conserved human Upf complex, a central component of NMD.

Integrating mRNA Processing with Transcription

Nascent Ribosomes

Pre-mRNA processing factors are required for nuclear export.

Analysis of mRNA nuclear export in living yeast cells shows the connections between mRNA processing and nuclear export.

Splicing is required for rapid and efficient mRNA export in metazoans.

  • M. LuoR. Reed
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1999
A link between splicing and efficient mRNA export is revealed, which may explain the reports that an intron is required for efficient expression of many protein-coding genes in metazoans.

Messenger RNAs are recruited for nuclear export during transcription.

Evidence that mRNAs are targeted for nuclear export cotranscriptionally is presented and it is suggested that export factors are recruited to the sites of transcription to promote efficient mRNA export.

The DECD box putative ATPase Sub2p is an early mRNA export factor