A Conserved Role for Drosophila Neuroglian and Human L1-CAM in Central-Synapse Formation

@article{Godenschwege2006ACR,
  title={A Conserved Role for Drosophila Neuroglian and Human L1-CAM in Central-Synapse Formation},
  author={Tanja A Godenschwege and Lars V. Kristiansen and Smitha B. Uthaman and Michael Hortsch and Rodney K. Murphey},
  journal={Current Biology},
  year={2006},
  volume={16},
  pages={12-23}
}
BACKGROUND Drosophila Neuroglian (Nrg) and its vertebrate homolog L1-CAM are cell-adhesion molecules (CAM) that have been well studied in early developmental processes. Mutations in the human gene result in a broad spectrum of phenotypes (the CRASH-syndrome) that include devastating neurological disorders such as spasticity and mental retardation. Although the role of L1-CAMs in neurite extension and axon pathfinding has been extensively studied, much less is known about their role in synapse… CONTINUE READING