A Conserved Motif in the C-terminal Tail of DNA Polymerase α Tethers Primase to the Eukaryotic Replisome*

@inproceedings{Kilkenny2012ACM,
  title={A Conserved Motif in the C-terminal Tail of DNA Polymerase α Tethers Primase to the Eukaryotic Replisome*},
  author={Mairi L. Kilkenny and Giacomo de Piccoli and Rajika L Perera and Karim Labib and Luca Pellegrini},
  booktitle={The Journal of biological chemistry},
  year={2012}
}
The DNA polymerase α-primase complex forms an essential part of the eukaryotic replisome. The catalytic subunits of primase and pol α synthesize composite RNA-DNA primers that initiate the leading and lagging DNA strands at replication forks. The physical basis and physiological significance of tethering primase to the eukaryotic replisome via pol α remain poorly characterized. We have identified a short conserved motif at the extreme C terminus of pol α that is critical for interaction of the… CONTINUE READING
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  • 2018
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