A Conserved Interaction between β1 Integrin/PAT-3 and Nck-Interacting Kinase/MIG-15 that Mediates Commissural Axon Navigation in C. elegans
@article{Poinat2002ACI, title={A Conserved Interaction between β1 Integrin/PAT-3 and Nck-Interacting Kinase/MIG-15 that Mediates Commissural Axon Navigation in C. elegans}, author={Patrice Poinat and A. Arcangelis and S. Sookhareea and X. Zhu and E. Hedgecock and M. Labouesse and E. Georges-Labouesse}, journal={Current Biology}, year={2002}, volume={12}, pages={622-631} }
BACKGROUND
Integrins are heterodimeric (alphabeta) transmembrane receptors for extracellular matrix (ECM) ligands. Through interactions with molecular partners at cell junctions, they provide a connection between the ECM and the cytoskeleton and regulate many aspects of cell behavior. A number of integrin-associated molecules have been identified; however, in many cases, their function and role in the animal remain to be clarified.
RESULTS
We have identified the Nck-interacting kinase (NIK… CONTINUE READING
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References
SHOWING 1-10 OF 57 REFERENCES
Characterization of beta pat-3 heterodimers, a family of essential integrin receptors in C. elegans
- Biology, Medicine
- The Journal of cell biology
- 1995
- 198
- PDF
Drosophila Integrin-Linked Kinase Is Required at Sites of Integrin Adhesion to Link the Cytoskeleton to the Plasma Membrane
- Biology, Medicine
- The Journal of cell biology
- 2001
- 284
- PDF
UNC-73 Activates the Rac GTPase and Is Required for Cell and Growth Cone Migrations in C. elegans
- Biology, Medicine
- Cell
- 1998
- 327
Cell-cell adhesion via the ECM: integrin genetics in fly and worm.
- Biology, Medicine
- Matrix biology : journal of the International Society for Matrix Biology
- 2000
- 120
beta1-integrin cytoplasmic subdomains involved in dominant negative function.
- Biology, Medicine
- Molecular biology of the cell
- 1998
- 83
- PDF
UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans
- Biology, Medicine
- Cell
- 1992
- 395
Neuronal Migrations and Axon Fasciculation Are Disrupted in ina-1 Integrin Mutants
- Biology, Medicine
- Neuron
- 1997
- 177