A Connectome of the Adult Drosophila Central Brain

@article{Xu2020ACO,
  title={A Connectome of the Adult Drosophila Central Brain},
  author={C. Xu and Michał Januszewski and Zhiyuan Lu and Shin-ya Takemura and K. Hayworth and Gary B. Huang and K. Shinomiya and Jeremy B. Maitin-Shepard and David Ackerman and Stuart E. Berg and T. Blakely and J. Bogovic and Jody Clements and Tom Dolafi and P. Hubbard and Dagmar Kainmueller and W. Katz and Takashi Kawase and K. Khairy and Laramie Leavitt and Peter H. Li and Larry Lindsey and Nicole L. Neubarth and D. J. Olbris and H. Otsuna and Eric T. Troutman and L. Umayam and Ting Zhao and Masayoshi Ito and Jens Goldammer and T. Wolff and R. Svirskas and P. Schlegel and E. Neace and Christopher J Knecht and Chelsea X. Alvarado and Dennis A Bailey and Samantha Ballinger and J. Borycz and Brandon S Canino and Natasha Cheatham and Michael Cook and M. Dreher and Octave Duclos and Bryon Eubanks and K. Fairbanks and Samantha Finley and N. Forknall and Audrey Francis and G. Hopkins and Emily M Joyce and SungJin Kim and Nicole A. Kirk and Julie Kovalyak and Shirley Lauchie and Alanna Lohff and Charli Maldonado and Emily A. Manley and Sari McLin and Caroline Mooney and Miatta Ndama and Omotara Ogundeyi and Nneoma Okeoma and Christopher Ordish and Nicholas Padilla and Christopher M Patrick and Tyler Paterson and Elliott E Phillips and E. M. Phillips and Neha Rampally and Caitlin Ribeiro and Madelaine K Robertson and J. Rymer and S. Ryan and Megan Sammons and Anne K. Scott and Ashley L. Scott and A. Shinomiya and Claire Smith and Kelsey Smith and Natalie L Smith and Margaret A. Sobeski and Alia Suleiman and Jackie Swift and Satoko Takemura and Iris Talebi and Dorota Tarnogorska and Emily Tenshaw and Temour Tokhi and J. Walsh and Tansy Yang and J. Horne and Feng Li and Ruchi Parekh and P. Rivlin and V. Jayaraman and Kei Ito and S. Saalfeld and R. George and I. Meinertzhagen and G. Rubin and H. Hess and Louis K. Scheffer and Viren Jain and Stephen M. Plaza},
  journal={bioRxiv},
  year={2020}
}
The neural circuits responsible for behavior remain largely unknown. Previous efforts have reconstructed the complete circuits of small animals, with hundreds of neurons, and selected circuits for larger animals. Here we (the FlyEM project at Janelia and collaborators at Google) summarize new methods and present the complete circuitry of a large fraction of the brain of a much more complex animal, the fruit fly Drosophila melanogaster. Improved methods include new procedures to prepare, image… Expand
A connectome and analysis of the adult Drosophila central brain
TLDR
Improved methods are summarized and the circuitry of a large fraction of the brain of the fruit fly Drosophila melanogaster is presented, reducing the effort needed to answer circuit questions and providing procedures linking the neurons defined by the analysis with genetic reagents. Expand
FlyBrainLab: Accelerating the Discovery of the Functional Logic of the Drosophila Brain in the Connectomic/Synaptomic Era
TLDR
FlyBrainLab seamlessly integrates and brings together computational models with neuroanatomical, neurogenetic and electrophysiological data, changing the organization of neuroscientific fly brain data from a group of seemingly disparate databases, arrays and tables, to a well structured data and executable circuit repository. Expand
Transsynaptic mapping of Drosophila mushroom body output neurons
TLDR
A multilayer circuit in which inhibitory and excitatory MBONs converge on the same genetic subset of FSB and LAL neurons enables the brain to update and integrate information with previous experience before executing appropriate behavioral responses. Expand
Uncovering the genetic blueprint of the C. elegans nervous system
TLDR
A computational framework is introduced to link the adjacency matrix of a connectome to the expression patterns of its neurons, helping to uncover a set of genetic rules that govern the interactions between neurons in contact. Expand
An unbiased template of the Drosophila brain and ventral nerve cord.
TLDR
This work created high-resolution templates of the Drosophila brain and ventral nerve cord using the best-available technologies for imaging, artifact correction, stitching, and template construction using groupwise registration and demonstrates that theirs enables more accurate registration with fewer local deformations in shorter time. Expand
Transsynaptic mapping of Drosophila mushroom body output neurons
TLDR
A multilayer circuit in which inhibitory and excitatory MBONs converge on the same genetic subset of FSB and LAL neurons provides an opportunity for the brain to update information and integrate it with previous experience before executing appropriate behavioral responses. Expand
Uncovering the genetic blueprint of the C. elegans nervous system
TLDR
A computational framework is introduced to link the adjacency matrix of a connectome to the expression patterns of its neurons, helping to uncover a set of genetic rules that govern the interactions between adjacent neurons. Expand
Functional connectomics spanning multiple areas of mouse visual cortex
TLDR
A unique functional connectomics dataset that contains calcium imaging of an estimated 75,000 neurons from primary visual cortex and three higher visual areas that were recorded while a mouse viewed natural movies and parametric stimuli is presented. Expand
Decoding gene regulation in the fly brain
The Drosophila brain is a work horse in neuroscience. Single-cell transcriptome analysis 1–5, 3D morphological classification 6, and detailed EM mapping of the connectome 7–10 have revealed anExpand
FlyWire: Online community for whole-brain connectomics
TLDR
FlyWire, an online community for proofreading neural circuits in a fly brain, is presented and it is demonstrated how FlyWire enables circuit analysis by reconstructing and analysing the connectome of mechanosensory neurons. Expand
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