A Connectome of the Adult Drosophila Central Brain

@article{Xu2020ACO,
  title={A Connectome of the Adult Drosophila Central Brain},
  author={C. Shan Xu and Michał Januszewski and Zhiyuan Lu and Shin-ya Takemura and Kenneth J. Hayworth and Gary B. Huang and Kazunori Shinomiya and Jeremy B. Maitin-Shepard and David Ackerman and Stuart E. Berg and Tim Blakely and John A. Bogovic and Jody Clements and Tom Dolafi and Philip M. Hubbard and Dagmar Kainmueller and William T. Katz and Takashi Kawase and Khaled A. Khairy and Laramie Leavitt and Peter H. Li and Larry F. Lindsey and Nicole L. Neubarth and Donald J. Olbris and Hideo Otsuna and Eric T. Troutman and Lowell A. Umayam and Ting Zhao and Masayoshi Ito and Jens Goldammer and Tanya Wolff and Robert R. Svirskas and Philipp Schlegel and Erika Rae Neace and Christopher J Knecht and Chelsea X. Alvarado and Dennis A Bailey and Samantha Ballinger and Jolanta A. Borycz and Brandon S Canino and Natasha Cheatham and Michael Cook and Marisa Dreher and Octave Duclos and Bryon Eubanks and Kelli Fairbanks and Samantha Finley and Nora Forknall and Audrey Francis and Gary Patrick Hopkins and Emily M Joyce and SungJin Kim and Nicole A. Kirk and Julie Kovalyak and Shirley Lauchie and Alanna Lohff and Charli Maldonado and Emily A. Manley and Sari McLin and Caroline Mooney and Miatta Ndama and Omotara Ogundeyi and Nneoma Okeoma and Christopher Ordish and Nicholas Padilla and Christopher M Patrick and Tyler Paterson and Elliott E Phillips and Emily M. Phillips and Neha Rampally and Caitlin Ribeiro and Madelaine K Robertson and Jon Thomson Rymer and Sean Michael Ryan and Megan Sammons and Anne K. Scott and Ashley L Scott and Aya Shinomiya and Claire Smith and Kelsey Smith and Natalie L Smith and Margaret A. Sobeski and Alia Suleiman and Jackie Swift and Satoko Takemura and Iris Talebi and Dorota Tarnogorska and Emily Tenshaw and Temour Tokhi and John J. Walsh and Tansy Yang and Jane Anne Horne and Feng Li and Ruchi Parekh and Patricia K. Rivlin and Vivek Jayaraman and Kei Ito and Stephan Saalfeld and Reed A. George and Ian A. Meinertzhagen and Gerald M. Rubin and Harald F. Hess and Louis K. Scheffer and Viren Jain and Stephen M. Plaza},
  journal={bioRxiv},
  year={2020}
}
The neural circuits responsible for behavior remain largely unknown. Previous efforts have reconstructed the complete circuits of small animals, with hundreds of neurons, and selected circuits for larger animals. Here we (the FlyEM project at Janelia and collaborators at Google) summarize new methods and present the complete circuitry of a large fraction of the brain of a much more complex animal, the fruit fly Drosophila melanogaster. Improved methods include new procedures to prepare, image… 
A connectome and analysis of the adult Drosophila central brain
TLDR
Improved methods are summarized and the circuitry of a large fraction of the brain of the fruit fly Drosophila melanogaster is presented, reducing the effort needed to answer circuit questions, and procedures linking the neurons defined by the analysis with genetic reagents are provided.
FlyBrainLab: Accelerating the Discovery of the Functional Logic of the Drosophila Brain in the Connectomic/Synaptomic Era
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FlyBrainLab seamlessly integrates and brings together computational models with neuroanatomical, neurogenetic and electrophysiological data, changing the organization of neuroscientific fly brain data from a group of seemingly disparate databases, arrays and tables, to a well structured data and executable circuit repository.
A connectome is not enough - what is still needed to understand the brain of Drosophila?
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Here, the data will need to be obtained, collate and organize in order to build an integrated model of the brain of D. melanogaster are itemized.
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A computational framework is introduced to link the adjacency matrix of a connectome to the expression patterns of its neurons, helping to uncover a set of genetic rules that govern the interactions between neurons in contact.
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This work reports for the first time obtaining joint functional and anatomical data from a major functional unit of the nervous system of the medicinal leech, by combining voltage-sensitive dye (VSD) imaging with serial blockface electron microscopy (SBEM).
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A unique functional connectomics dataset that contains calcium imaging of an estimated 75,000 neurons from primary visual cortex and three higher visual areas that were recorded while a mouse viewed natural movies and parametric stimuli is presented.
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The results confirm that the Drosophila heading direction network contains the core components of a ring attractor while also revealing unpredicted structural features that might enable the heading system to accurately track the animal’s heading with a small number of neurons.
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