A Conformationally Restricted β-Strand HIV Protease Inhibitor.

Abstract

The use of cyclopropanes as a conformationally restricted subunits in biological systems has been the subject of intense study by our group and others (1-10). Our recent efforts have focused on the use of 1, 2, 3-trisubstituted cyclopropanes as novel [-NH-Cα-] or [-CO-Cα-] bond replacements in pseudopeptides to restrict both side-chain orientation and… (More)
DOI: 10.1385/0-89603-517-4:397

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