A Conditional Zebrafish MITF Mutation Reveals MITF Levels Are Critical for Melanoma Promotion vs. Regression In Vivo

@inproceedings{Lister2014ACZ,
  title={A Conditional Zebrafish MITF Mutation Reveals MITF Levels Are Critical for Melanoma Promotion vs. Regression In Vivo},
  author={James A Lister and Amy Capper and Zhiqiang Zeng and Marie E. Mathers and Jennifer Richardson and Karthika Paranthaman and Ian J Jackson and E Elizabeth Patton},
  booktitle={The Journal of investigative dermatology},
  year={2014}
}
The microphthalmia-associated transcription factor (MITF) is the "master melanocyte transcription factor" with a complex role in melanoma. MITF protein levels vary between and within clinical specimens, and amplifications and gain- and loss-of-function mutations have been identified in melanoma. How MITF functions in melanoma development and the effects of targeting MITF in vivo are unknown because MITF levels have not been directly tested in a genetic animal model. Here, we use a temperature… CONTINUE READING
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