A Conceptualization of Integrated Actions of Ethanol Contributing to its GABAmimetic Profile: A Commentary

@article{Criswell2005ACO,
  title={A Conceptualization of Integrated Actions of Ethanol Contributing to its GABAmimetic Profile: A Commentary},
  author={Hugh E. Criswell and George R. Breese},
  journal={Neuropsychopharmacology},
  year={2005},
  volume={30},
  pages={1407-1425}
}
Early behavioral investigations supported the contention that systemic ethanol displays a GABAmimetic profile. Microinjection of GABA agonists into brain and in vivo electrophysiological studies implicated a regionally specific action of ethanol on GABA function. While selectivity of ethanol to enhance the effect of GABA was initially attributed an effect on type-1-benzodiazepine (BZD)-GABAA receptors, a lack of ethanol's effect on GABA responsiveness from isolated neurons with this receptor… CONTINUE READING
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Effects of alcohol on ion channels in brainFa new look

  • HE Criswell, GR Breese
  • In: Preedy VR, Watson RR (eds). Comprehensive…
  • 2005
Highly Influential
4 Excerpts

Comparison of the effect of ethanol on NMDA- and GABA-gated currents from acutely dissociated neurons: absence of regional differences in sensitivity to ethanol

  • HE Criswell, Z Ming, BL Griffin, RA Mueller, GR Breese
  • J Pharmacol Exp Ther 304: 192–199.
  • 2003
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