A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells

@article{Procko2014ACD,
  title={A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells},
  author={Erik Procko and Geoffrey Y. Berguig and Betty W. Shen and Yifan Song and Shani L. Frayo and Anthony J Convertine and Daciana H. Margineantu and Garrett C. Booth and Bruno E. Correia and Yuanhua Cheng and William R. Schief and David M. Hockenbery and Oliver W Press and Barry L. Stoddard and Patrick S. Stayton and David Baker},
  journal={Cell},
  year={2014},
  volume={157},
  pages={1644-1656}
}
Because apoptosis of infected cells can limit virus production and spread, some viruses have co-opted prosurvival genes from the host. This includes the Epstein-Barr virus (EBV) gene BHRF1, a homolog of human Bcl-2 proteins that block apoptosis and are associated with cancer. Computational design and experimental optimization were used to generate a novel protein called BINDI that binds BHRF1 with picomolar affinity. BINDI recognizes the hydrophobic cleft of BHRF1 in a manner similar to other… CONTINUE READING
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