A Computational Study on the Relation between Resting Heart Rate and Atrial Fibrillation Hemodynamics under Exercise

  title={A Computational Study on the Relation between Resting Heart Rate and Atrial Fibrillation Hemodynamics under Exercise},
  author={Matteo Anselmino and Stefania Scarsoglio and Andrea Saglietto and Fiorenzo Gaita and Luca Ridolfi},
  journal={PLoS ONE},
Aims Clinical data indicating a heart rate (HR) target during rate control therapy for permanent atrial fibrillation (AF) and assessing its eventual relationship with reduced exercise tolerance are lacking. The present study aims at investigating the impact of resting HR on the hemodynamic response to exercise in permanent AF patients by means of a computational cardiovascular model. Methods The AF lumped-parameter model was run to simulate resting (1 Metabolic Equivalent of Task—MET) and… 

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