A Computational Study on the Relation between Resting Heart Rate and Atrial Fibrillation Hemodynamics under Exercise

@article{Anselmino2017ACS,
  title={A Computational Study on the Relation between Resting Heart Rate and Atrial Fibrillation Hemodynamics under Exercise},
  author={Matteo Anselmino and Stefania Scarsoglio and Andrea Saglietto and Fiorenzo Gaita and Luca Ridolfi},
  journal={PLoS ONE},
  year={2017},
  volume={12}
}
Aims Clinical data indicating a heart rate (HR) target during rate control therapy for permanent atrial fibrillation (AF) and assessing its eventual relationship with reduced exercise tolerance are lacking. The present study aims at investigating the impact of resting HR on the hemodynamic response to exercise in permanent AF patients by means of a computational cardiovascular model. Methods The AF lumped-parameter model was run to simulate resting (1 Metabolic Equivalent of Task—MET) and… 

Figures and Tables from this paper

A computational analysis of atrial fibrillation effects on coronary perfusion across the different myocardial layers
TLDR
It is shown that AF exerts direct hemodynamic consequences on the coronary microcirculation, causing a reduction in microvascular coronary flow particularly at higher ventricular rates; the most prominent reduction was seen in the subendocardial layers perfused by left coronary arteries (left anterior descending and left circumflex arteries).
Different Impact of Heart Rate Variability in the Deep Cerebral and Central Hemodynamics at Rest: An in silico Investigation
TLDR
This work proposes a computational approach to evaluate the deep cerebral and central hemodynamics subject to physiological alterations of HRV in an ideal young healthy patient at rest and suggests that the optimal HRV configuration is found at baseline.
Higher ventricular rate during atrial fibrillation relates to increased cerebral hypoperfusions and hypertensive events
TLDR
Higher ventricular rates relate to a progressive increase in critical cerebral hemodynamic events (hypoperfusions and hypertensive events) at the distal cerebral circle, suggesting that a rate control strategy aiming to around 60 bpm could be beneficial in terms on cognitive outcomes in patients with permanent AF.
Alteration of cerebrovascular haemodynamic patterns due to atrial fibrillation: an in silico investigation
TLDR
An in silico approach is proposed that combines in sequence two lumped-parameter schemes, for the cardiovascular system and the cerebral circulation, with the aim of studying the role of AF on the cerebral haemodynamics with respect to normal sinus rhythm.
Numerical Study of Atrial Fibrillation Effects on Flow Distribution in Aortic Circulation
TLDR
A parametric study to quantify the sensitivity of aortic flow to four common AF traits including lack of atrial kick, atrial remodelling, left ventricle systolic dysfunction, and high frequency fibrillation reveals that AF traits lower flow rate at left ventricular outflow tract, which in general lowers blood perfusion to systemic, cerebral and coronary circulations.
Atrial Fibrillation and Anterior Cerebral Artery Absence Reduce Cerebral Perfusion: A De Novo Hemodynamic Model
TLDR
A novel cardio-cerebral lumped parameter hemodynamic model is developed to investigate the role of CoW variants on cerebral blood flow dynamics under atrial fibrillation conditions and suggests that CoW geometry plays an important role in influencing cerebral hemodynamics during atrialfibrillation.
From time-series to complex networks: Application to the cerebrovascular flow patterns in atrial fibrillation.
TLDR
Through a powerful approach which is complementary to the classical statistical tools, the present findings further strengthen the potential link between AF hemodynamic and cognitive decline.
Using a Human Circulation Mathematical Model to Simulate the Effects of Hemodialysis and Therapeutic Hypothermia
TLDR
Clinical measurables that may be used as surrogates to diagnose underlying diseases such as atrial fibrillation and hypothermia are suggested.
...
...

References

SHOWING 1-10 OF 42 REFERENCES
The relationship between resting heart rate and peak VO2: A comparison of atrial fibrillation and sinus rhythm
TLDR
The impact of resting heart rate on exercise capacity differed completely between atrial fibrillation and sinus rhythm, suggesting that heart rate control may need to be managed differently for atrial gynaecological conditions, in light of exercise capacity that is related to quality of life and prognosis.
Rate Control Management of Atrial Fibrillation: May a Mathematical Model Suggest an Ideal Heart Rate?
TLDR
The present mathematical model suggests that lower HRs during permanent AF relates to improved hemodynamic parameters, cardiac efficiency, and lower oxygen consumption.
Computational fluid dynamics modelling of left valvular heart diseases during atrial fibrillation
TLDR
It is revealed that both mitral and aortic regurgitation strongly affect hemodynamics, followed by mitral stenosis, while aorti stenosis has the least impact among the analyzed valvular diseases.
Impact of atrial fibrillation on the cardiovascular system through a lumped-parameter approach
TLDR
Modeling the global response of the cardiovascular system during paroxysmal AF through a lumped-parameter approach, providing new insights on cardiovascular variables which are difficult to measure and rarely reported in literature, turns out to be an efficient and powerful tool for a deeper comprehension and prediction of the arrythmia impact on the whole cardiovascular system.
Hemodynamic basis of exercise limitation in patients with heart failure and normal ejection fraction.
The sex-specific impact of systolic hypertension and systolic blood pressure on arterial-ventricular coupling at rest and during exercise.
TLDR
SH and a higher resting brachial SBP are associated with a lower E(a)I/E(LV)I at rest in women but not in men, and SH women have an attenuated E( a)I-E( LV)I reserve.
Exercise intolerance in patients with atrial fibrillation: clinical and echocardiographic determinants of exercise capacity.
  • Sang Hak Lee, Jae‐Hun Jung, Yung Lee
  • Medicine
    Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
  • 2005
Reduced stroke volume during exercise in postural tachycardia syndrome
The Effects of Atrial Fibrillation on Atrial Pressure‐ Volume and Flow Relationships
TLDR
Atrial fibrillation alters atrial hemodynamics and metabolism by increasing atrial blood flow and oxygen consumption and decreasing atrial distensibility and it is possible that additional atrial metabolic requirements might lead to atrial ischemia, fibrosis, and, thereby, perpetuation of the arrhythmia.
...
...