A Computational Study of the Glycine-Rich Loop of Mitochondrial Processing Peptidase

@inproceedings{Kuera2013ACS,
  title={A Computational Study of the Glycine-Rich Loop of Mitochondrial Processing Peptidase},
  author={Tom{\'a}{\vs} Ku{\vc}era and Michal Otyepka and Anna Matu{\vs}kov{\'a} and Abdul Samad and Eva Kutějov{\'a} and Jiri Janata},
  booktitle={PloS one},
  year={2013}
}
An all atomic, non-restrained molecular dynamics (MD) simulation in explicit water was used to study in detail the structural features of the highly conserved glycine-rich loop (GRL) of the α-subunit of the yeast mitochondrial processing peptidase (MPP) and its importance for the tertiary and quaternary conformation of MPP. Wild-type and GRL-deleted MPP structures were studied using non-restrained MD simulations, both in the presence and the absence of a substrate in the peptidase active site… CONTINUE READING