A Computational Model of the LGI1 Protein Suggests a Common Binding Site for ADAM Proteins

@inproceedings{Leonardi2011ACM,
  title={A Computational Model of the LGI1 Protein Suggests a Common Binding Site for ADAM Proteins},
  author={Emanuela Leonardi and Simonetta Andreazza and Stefano Vanin and Giorgia Busolin and Carlo Nobile and Silvio C E Tosatto},
  booktitle={PloS one},
  year={2011}
}
Mutations of human leucine-rich glioma inactivated (LGI1) gene encoding the epitempin protein cause autosomal dominant temporal lateral epilepsy (ADTLE), a rare familial partial epileptic syndrome. The LGI1 gene seems to have a role on the transmission of neuronal messages but the exact molecular mechanism remains unclear. In contrast to other genes involved in epileptic disorders, epitempin shows no homology with known ion channel genes but contains two domains, composed of repeated structural… CONTINUE READING