A Computational Model of Oncogenesis using the Systemic Approach

  title={A Computational Model of Oncogenesis using the Systemic Approach},
  author={Sorinel Adrian Oprisan and Ana Oprisan},
A new theoretical model of oncogenesis that incorporates a systemic view of biodynamics was developed and analyzed. According to our model, the emergent behavior at the cell population level is the result of nonlinear interactions between the neoplastic and immune subsystems. Our approach allows subsequent extensions of the model to span multiple levels of biological organization. The model opens the possibility of a flexible connection between the molecular and tissue level descriptions of… Expand
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Rules for making human tumor cells.
The authors propose a considerably simplified scheme in which only five alterations are required to transform cells from a normal to a malignant phenotype. Expand
Modelling the molecular circuitry of cancer
By rationalizing the shared and unique elements of human and mouse models of cancer, this work should be able to identify the molecular circuits that function differently in humans and mice, and use this knowledge to improve existing models ofcancer. Expand
Oncogenes, anti-oncogenes and the immune response to cancer : a mathematical model
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  • Biology, Medicine
  • Proceedings of the Royal Society of London. Series B: Biological Sciences
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The results suggest that the effectiveness of the immune response after an oncogenic mutation depends crucially on the way in which the mutation affects the biochemical control of cell division. Expand
A cellular automaton model of cancerous growth.
A cellular automaton model describing immune system surveillance against cancer is furnished, which may describe the Gompertz growth of a cancer. Expand
Evolution of tumours attacked by immune cytotoxic cells: The immune response dilemma
This chapter describes the evolution of tumors attacked by immune cytotoxic cells, which indicates that in many tumors, cancer cells are not only continuously produced but are also continuously killed. Expand
Self-organization and competition in the immune response to cancer invasion: a phase-orientated computational model of oncogenesis
A new theoretical model incorporating a systemic view of oncogenesis in a computational model is proposed that revealed that tumor escape can be uncovered in some earlier stage of the immune-system-tumor interaction using multifractal measures. Expand
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Three to six mutations appear to be required to complete the process of cellular multiplication associated with gradual increases in tumor size, disorganization and malignancy in cancer. Expand
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Details of work at the cellular level of "spontaneous" neoplastic transformation in culture are described to point out parallels with the development of cancer in the organism. Expand
Initiation of genetic instability and tumour formation: a review and hypothesis of a nongenotoxic mechanism
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  • Biology, Medicine
  • Cellular and Molecular Life Sciences CMLS
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A nonmutational (nongenotoxic) mechanism of initiation of genetic instability in previously normal cells as follows are proposed: during S phase of local tissue stem cells, carcinogen binds to and disables the proofreading enzyme for a new DNA strand. Expand