A Computational Model of Direct Interstitial Infusion of Macromolecules into the Spinal Cord

Abstract

Convection-enhanced interstitial infusion can deliver macromolecular drugs to large tissue volumes of the central nervous system. To characterize infusion into the spinal cord, an image-based three-dimensional finite element model of the rat spinal cord was developed. The model incorporated convection and diffusion through white and gray matter, including… (More)
DOI: 10.1114/1.1558032

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