A Computational Model for Predicting Nanoparticle Accumulation in Tumor Vasculature

@inproceedings{Frieboes2013ACM,
  title={A Computational Model for Predicting Nanoparticle Accumulation in Tumor Vasculature},
  author={Hermann B. Frieboes and Min Wu and John Lowengrub and Paolo Decuzzi and Vittorio Cristini},
  booktitle={PloS one},
  year={2013}
}
Vascular targeting of malignant tissues with systemically injected nanoparticles (NPs) holds promise in molecular imaging and anti-angiogenic therapies. Here, a computational model is presented to predict the development of tumor neovasculature over time and the specific, vascular accumulation of blood-borne NPs. A multidimensional tumor-growth model is integrated with a mesoscale formulation for the NP adhesion to blood vessel walls. The fraction of injected NPs depositing within the diseased… CONTINUE READING
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