A Computational Model for Glycogenolysis in Skeletal Muscle

  title={A Computational Model for Glycogenolysis in Skeletal Muscle},
  author={Melissa J. Lambeth and Martin J. Kushmerick},
  journal={Annals of Biomedical Engineering},
A dynamic model of the glycogenolytic pathway to lactate in skeletal muscle was constructed with mammalian kinetic parameters obtained from the literature. Energetic buffers relevant to muscle were included. The model design features stoichiometric constraints, mass balance, and fully reversible thermodynamics as defined by the Haldane relation. We employed a novel method of validating the thermodynamics of the model by allowing the closed system to come to equilibrium; the combined mass action… CONTINUE READING
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