A Computational Hypothesis for Allostasis: Delineation of Substance Dependence, Conventional Therapies, and Alternative Treatments

The allostatic theory of drug abuse describes the brain's reward system alterations as substance misuse progresses. Neural adaptations arising from the reward system itself and from the antireward system provide the subject with functional stability, while affecting the person's mood. We propose a computational hypothesis describing how a virtual subject's… CONTINUE READING