A Comprehensive Review of the Pharmacodynamics, Pharmacokinetics, and Clinical Effects of the Neutral Endopeptidase Inhibitor Racecadotril

@inproceedings{Eberlin2012ACR,
  title={A Comprehensive Review of the Pharmacodynamics, Pharmacokinetics, and Clinical Effects of the Neutral Endopeptidase Inhibitor Racecadotril},
  author={Marion Eberlin and Tobias Mueck and Martin C Michel},
  booktitle={Front. Pharmacol.},
  year={2012}
}
Racecadotril, via its active metabolite thiorphan, is an inhibitor of the enzyme neutral endopeptidase (NEP, EC 3.4.24.11), thereby increasing exposure to NEP substrates including enkephalins and atrial natriuretic peptide (ANP). Upon oral administration racecadotril is rapidly and effectively converted into the active metabolite thiorphan, which does not cross the blood-brain-barrier. Racecadotril has mainly been tested in animal models and patients of three therapeutic areas. As an analgesic… CONTINUE READING
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Racecadotril

  • A. J. Matheson, S. Noble
  • Drugs 59, 829–835.
  • 2000
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