A Comprehensive Review of Punica granatum (Pomegranate) Properties in Toxicological, Pharmacological, Cellular and Molecular Biology Researches

@article{Rahimi2012ACR,
  title={A Comprehensive Review of Punica granatum (Pomegranate) Properties in Toxicological, Pharmacological, Cellular and Molecular Biology Researches},
  author={Hamid Reza Rahimi and Mohammad Reza Arastoo and Seyed Nasser Ostad},
  journal={Iranian Journal of Pharmaceutical Research : IJPR},
  year={2012},
  volume={11},
  pages={385 - 400}
}
Punica granatum (Pg), commonly known as pomegranate (Pg), is a member of the monogeneric family, Punicaceae, and is mainly found in Iran which is considered to be its primary centre of origin. Pg and its chemical components possess various pharmacological and toxicological properties including antioxidant, anti-inflammatory (by inhibiting pro-inflammatory cytokines), anti-cancer and anti-angiogenesis activities. They also show inhibitory effects on invasion/motility, cell cycle, apoptosis, and… 
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References

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Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells.
TLDR
The polyphenolic phytochemicals in the pomegranate can play an important role in the modulation of inflammatory cell signaling in colon cancer cells.
Protective effects of standardized pomegranate (Punica granatum L.) polyphenolic extract in ultraviolet-irradiated human skin fibroblasts.
TLDR
Pomegranate extract was effective at protecting human skin fibroblasts from cell death following UV exposure, likely related to a reduced activation of the pro-inflammatory transcription factor NF-kappaB, a downregulation of proapoptotic caspase-3, and an increased G0/G1 phase, associated with DNA repair.
Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel™
TLDR
Four pure chemicals, ellagic acid (E), caffeic acid (C), luteolin (L) and punicic Acid (P), all important components of the aqueous compartments or oily compartment of pomegranate fruit, were tested as potential inhibitors of in vitro invasion of human PC-3 prostate cancer cells in an assay employing Matrigel™ artificial membranes.
Effect of pomegranate (Punica granatum) juice intake on hepatic oxidative stress
TLDR
Protection against protein and DNA oxidation was found in PJ group and RT-PCR results showed that GST and GS transcription were also decreased in this group, compatible with a protective effect of PJ against systemic oxidative stress in mice.
Antioxidant activities of pomegranate fruit extract and its anthocyanidins: delphinidin, cyanidin, and pelargonidin.
TLDR
It is suggested that the above anthocyanidins contribute to the antioxidant activity of pomegranate fruits.
Pomegranate Ellagitannin–Derived Compounds Exhibit Antiproliferative and Antiaromatase Activity in Breast Cancer Cells In vitro
TLDR
Pomegranate ET–derived compounds have potential for the prevention of estrogen-responsive breast cancers, and urolithin B (UB) was shown to most effectively inhibit aromatase activity in a live cell assay.
In vitro studies on the binding, antioxidant, and cytotoxic actions of punicalagin.
TLDR
In vitro cytotoxic studies against three cell lines, namely, Vero (normal African green monkey kidney cell line), Hep-2 (human larynx epithelial cancer cell line, and A-549 (human small cell lung carcinoma cell line) showed that this polyphenol is toxic only at higher concentration.
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TLDR
Pomegranate juice consumption decreased total hepatic CYP content as well as the expression of CYP1A2 and CYP3A, and Prevention of procarcinogen activation through CYP activity/expression inhibition may be involved in pomegranATE juice's effect on tumor initiation, promotion, and progression.
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