A Comprehensive Review of Punica granatum (Pomegranate) Properties in Toxicological, Pharmacological, Cellular and Molecular Biology Researches

@article{Rahimi2012ACR,
  title={A Comprehensive Review of Punica granatum (Pomegranate) Properties in Toxicological, Pharmacological, Cellular and Molecular Biology Researches},
  author={Hamid Reza Rahimi and Mohammad R. Arastoo and Seyed Nasser Ostad},
  journal={Iranian Journal of Pharmaceutical Research : IJPR},
  year={2012},
  volume={11},
  pages={385 - 400}
}
Punica granatum (Pg), commonly known as pomegranate (Pg), is a member of the monogeneric family, Punicaceae, and is mainly found in Iran which is considered to be its primary centre of origin. Pg and its chemical components possess various pharmacological and toxicological properties including antioxidant, anti-inflammatory (by inhibiting pro-inflammatory cytokines), anti-cancer and anti-angiogenesis activities. They also show inhibitory effects on invasion/motility, cell cycle, apoptosis, and… Expand
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References

SHOWING 1-10 OF 154 REFERENCES
Differentiation-promoting activity of pomegranate (Punica granatum) fruit extracts in HL-60 human promyelocytic leukemia cells.
TLDR
The results highlight an important, previously unknown, mechanism of the cancer preventive and suppressive potential of pomegranate fermented juice and pericarp extracts. Expand
Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells.
TLDR
The polyphenolic phytochemicals in the pomegranate can play an important role in the modulation of inflammatory cell signaling in colon cancer cells. Expand
Broad spectrum antimutagenic activity of antioxidant active fraction of punica granatum L. peel extracts.
TLDR
High content of ellagitannins is revealed which might be responsible for promising antioxidant and antimutagenic activities of P. granatum peel extract which is to be explored to understand the exact mechanism of action as well as their therapeutic efficacy. Expand
Protective effects of standardized pomegranate (Punica granatum L.) polyphenolic extract in ultraviolet-irradiated human skin fibroblasts.
TLDR
Pomegranate extract was effective at protecting human skin fibroblasts from cell death following UV exposure, likely related to a reduced activation of the pro-inflammatory transcription factor NF-kappaB, a downregulation of proapoptotic caspase-3, and an increased G0/G1 phase, associated with DNA repair. Expand
Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel™
TLDR
Four pure chemicals, ellagic acid (E), caffeic acid (C), luteolin (L) and punicic Acid (P), all important components of the aqueous compartments or oily compartment of pomegranate fruit, were tested as potential inhibitors of in vitro invasion of human PC-3 prostate cancer cells in an assay employing Matrigel™ artificial membranes. Expand
Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism.
TLDR
The results suggest that UROA could be the most active anti-inflammatory compound derived from pomegranate ingestion in healthy subjects, whereas in colon inflammation, the effects could be due to the nonmetabolized ellagitannin-related fraction. Expand
Effect of pomegranate (Punica granatum) juice intake on hepatic oxidative stress
TLDR
Protection against protein and DNA oxidation was found in PJ group and RT-PCR results showed that GST and GS transcription were also decreased in this group, compatible with a protective effect of PJ against systemic oxidative stress in mice. Expand
Antioxidant activities of pomegranate fruit extract and its anthocyanidins: delphinidin, cyanidin, and pelargonidin.
TLDR
It is suggested that the above anthocyanidins contribute to the antioxidant activity of pomegranate fruits. Expand
The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma Caco-2 cells by using the mitochondrial pathway.
TLDR
This study suggests that the anticarcinogenic effect of dietary ETs could be mainly due to their hydrolysis product, EA, which induced apoptosis via mitochondrial pathway in colon cancer Caco-2 cells but not in normal colon cells. Expand
Pomegranate Ellagitannin–Derived Compounds Exhibit Antiproliferative and Antiaromatase Activity in Breast Cancer Cells In vitro
TLDR
Pomegranate ET–derived compounds have potential for the prevention of estrogen-responsive breast cancers, and urolithin B (UB) was shown to most effectively inhibit aromatase activity in a live cell assay. Expand
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