A Comprehensive Review of Biomarker Use in the Gynecologic Tract Including Differential Diagnoses and Diagnostic Pitfalls.

@article{Hirsch2019ACR,
  title={A Comprehensive Review of Biomarker Use in the Gynecologic Tract Including Differential Diagnoses and Diagnostic Pitfalls.},
  author={Michelle S. Hirsch and Jaclyn C Watkins},
  journal={Advances in Anatomic Pathology},
  year={2019}
}
Morphologic (ie, hematoxylin and eosin) evaluation of the Mullerian tract remains the gold standard for diagnostic evaluation; nevertheless, ancillary/biomarker studies are increasingly utilized in daily practice to assist in the subclassification of gynecologic lesions and tumors. The most frequently utilized "biomarker" technique is immunohistochemistry; however, in situ hybridization (chromogenic and fluorescence), chromosomal evaluation, and molecular analysis can also be utilized to aid in… Expand
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References

SHOWING 1-10 OF 253 REFERENCES
Immunohistochemistry in Gynecologic Pathology: An Example-Based Practical Update.
  • N. Buza, P. Hui
  • Medicine
  • Archives of pathology & laboratory medicine
  • 2017
TLDR
Although the primary application is in the diagnostic workup, novel prognostic and predictive markers, and immunostains to screen for genetic cancer syndromes, have also been recently introduced in the field. Expand
The utility of immunohistochemistry in the differential diagnosis of gynecologic disorders.
TLDR
The utilities and pitfalls of the commonly used immunohistochemical markers in the context of overlapping morphologic features encountered in the uterus, ovaries, and fallopian tubes are discussed. Expand
Overdiagnosis of HSIL on cervical biopsy: errors in p16 immunohistochemistry implementation.
TLDR
A standardized threshold for p16 positivity and supplementary guidance will help clarify the biomarker's utility and will facilitate LAST implementation in routine practice and identify challenges and errors in p16 IHC implementation. Expand
Immunohistochemistry as a diagnostic aid in cervical pathology
TLDR
P63, a useful marker of squamous neoplasms within the cervix, is of value in distinguishing small cell neuroendocrine carcinoma from small cell squamous carcinoma and in confirming that a poorly differentiated carcinoma is squamous in type. Expand
Tissue-based Immunohistochemical Biomarker Expression in Malignant Glandular Lesions of the Uterine Cervix: A Systematic Review
TLDR
Biomarker expression in the discrimination of AIS from invasive adenocarcinoma, and the invasive histotypes from each other is understudied, and one or more of 15 biomarkers could have diagnostic utility. Expand
The spectrum of cervical glandular neoplasia and issues in differential diagnosis.
TLDR
Clinical and morphologic features as well as immunohistochemistry results should be used in conjunction in the differential diagnosis of glandular proliferations of the cervix, as correct interpretation has major clinical consequences for the patient in most instances. Expand
Practical issues in uterine pathology from banal to bewildering: the remarkable spectrum of smooth muscle neoplasia
  • E. Oliva
  • Biology, Medicine
  • Modern Pathology
  • 2016
TLDR
Among mesenchymal tumors of the uterus, smooth muscle neoplasms are most common and endometrial stromal tumors are by far, less common than smooth muscle tumors, but can be confused with leiomyosarcomas if they are associated with an undifferentiated uterine sarcoma and the low-grade component is overlooked. Expand
Immunohistochemical Staining in the Distinction Between Primary Endometrial and Endocervical Adenocarcinomas: Another Viewpoint
TLDR
Both site and differentiation influenced these results, with the latter more important for VIM and PR, the former for ER, both for CEA (only mEC was frequently strongly positive, and neither for the CKs studied), suggesting with about 95% accuracy in this series an endometrial origin of the tumor. Expand
p16 Expression in the Female Genital Tract and Its Value in Diagnosis
TLDR
In cervical squamous lesions, p16 is positive in most high-grade cervical intraepithelial neoplasia (CIN) and in some cases of low-grade CIN, usually those associated with high-risk HPV, whereas the more common non-HPV-associated neoplasms are largely negative or focally positive. Expand
Perivascular epithelioid cell neoplasm (PEComa) of the uterus: A systematic review.
TLDR
Although the optimal treatment of gynecological PEComas is controversial, surgical resection remains the cornerstone and the use of adjuvant treatment is warranted in high risk patients to increase disease control. Expand
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