A Comprehensive Genetic Analysis of Candidate Genes Regulating Response to Trypanosoma congolense Infection in Mice

  title={A Comprehensive Genetic Analysis of Candidate Genes Regulating Response to Trypanosoma congolense Infection in Mice},
  author={I. Goodhead and A. Archibald and Peris Amwayi and A. Brass and J. Gibson and N. Hall and M. Hughes and M. Limo and F. Iraqi and S. Kemp and H. Noyes},
  journal={PLoS Neglected Tropical Diseases},
  • I. Goodhead, A. Archibald, +8 authors H. Noyes
  • Published 2010
  • Biology, Medicine
  • PLoS Neglected Tropical Diseases
  • Background African trypanosomes are protozoan parasites that cause “sleeping sickness” in humans and a similar disease in livestock. Trypanosomes also infect laboratory mice and three major quantitative trait loci (QTL) that regulate survival time after infection with T. congolense have been identified in two independent crosses between susceptible A/J and BALB/c mice, and the resistant C57BL/6. These were designated Tir1, Tir2 and Tir3 for Trypanosoma infection response, and range in size from… CONTINUE READING
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